Mendelian randomization is a method for causal inference that leverages the random inheritance of alleles as instrumental variables to estimate the causal effects of exposures on outcomes 1,2,3,4 (Box ...
Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian ...
Anyone who’s read my stuff with any regularity is acutely aware of my disdain for the way many observational studies are conducted and interpreted in health and nutrition research, as well as my ...
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